Increased Copper Metallothionein in Menkes Cultured Skin Fibroblasts
نویسندگان
چکیده
منابع مشابه
Role of Cultured Skin Fibroblasts in Aesthetic and Plastic Surgery
The skin is the largest tissue of man with several functions. Cosmetics/cosmeceuticals agents always are needed to be evaluated for their detrimental effects on the skin. Nowadays, the therapeutic potential of stem cells has and fibroblasts have increased the hope for a successful cell therapy in aesthetic medicine. Stem cells are unspecialized cells capable of renewing themselves through cell ...
متن کاملMenkes disease: a biochemical abnormality in cultured human fibroblasts.
Cultured skin fibroblasts from patients with Menkes disease, an X-linked disorder involving a defect in copper metabolism, were analyzed for copper concentration by means of atomic absorption spectrophotometry. These cultures consistently exhibited elevated copper concentrations (mean = 335.5 ng of copper per mg of protein) when compared to control fibroblast cultures (mean = 59.2 ng of copper ...
متن کاملrole of cultured skin fibroblasts in aesthetic and plastic surgery
the skin is the largest tissue of man with several functions. cosmetics/cosmeceuticals agents always are needed to be evaluated for their detrimental effects on the skin. nowadays, the therapeutic potential of stem cells has and fibroblasts have increased the hope for a successful cell therapy in aesthetic medicine. stem cells are unspecialized cells capable of renewing themselves through cell ...
متن کاملIncreased calmodulin in cultured skin fibroblasts from patients with cystic fibrosis.
Alterations of both cyclic AMP and calcium metabolism have been found in many cell types from patients with cystic fibrosis (CF). Several groups have reported an increase in intracellular cyclic AMP in CF fibroblasts after stimulation with isoproterenol (1,2). These results have been confirmed by Markovac et al. and are reported in the accompanying paper (3). Markovac ef al. (3) also found incr...
متن کاملA copper treatable Menkes disease mutation associated with defective trafficking of a functional Menkes copper ATPase.
Copper dependency in humans is most dramatically illustrated in Menkes disease, an X linked recessive copper deficiency disorder that is generally lethal in early childhood. 2 Menkes disease is caused by mutations in a transmembrane copper transporting P type ATPase, MNK (or ATP7A), which is expressed in virtually all non-hepatic tissues. Studies using cultured cells suggest that MNK is located...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1981
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198103000-00012